Predicting Response to Vedolizumab in Anti-TNF Refractory IBD Patients Using PIMS® Technology
Abstract Background Inflammatory Bowel Disease (IBD), including Crohn’s disease and ulcerative colitis, is a chronic condition that significantly impacts patients’ quality of life. While biologic therapies like anti-TNF agents have revolutionized treatment, a substantial proportion of patients do not respond to these therapies. Vedolizumab, an anti-integrin antibody, offers an alternative for patients refractory to anti-TNF […]
PIMS Knowledge center
Physiological Intermolecular Modulation Spectroscopy (PIMS®) is a patented, label-free technology that uses near-infrared (NIR) spectroscopy to probe the interactions between therapeutic agents (e.g., drugs, peptides, biologics) and their molecular targets (e.g., proteins) in a patient’s biological sample. Unlike traditional assays that often require fluorescent or radioactive labeling, PIMS® exploits water molecule resonance as a direct […]
LIPS Knowledge center
LIPS (Ligand Induced Phase Shift) is an innovative, label-free method developed to evaluate functional target engagement within disease models. By leveraging the intrinsic changes in a protein’s physicochemical properties upon drug binding, LIPS offers a sensitive and quantitative way to monitor how drugs interact with their targets in both cultured cell lines and diseased human […]
NPOT Knowledge center
Nematic Protein Organization Technique (NPOT®) is a groundbreaking, label-free platform that isolates and identifies the drug-induced interactome; the dynamic network of proteins interacting directly and indirectly with a therapeutic compound. NPOT® operates directly in native biological matrices, including cell lines, human/animal tissue homogenates, and pathological samples (e.g., biopsies), preserving physiological protein conformations and interactions. Compatible with small molecules, therapeutic antibodies (mono-/multi-specific), peptides, and high molecular […]
